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Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection. 2024 Jun 9; PMID: 38931171 PMCID: PMC11206249 DOI: 10.3390/nu16121816
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Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells. 2024 Jan 25:e170961. doi: 10.1172/jci.insight.170961. Online ahead of print.
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L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary. 2022 Dec 12;5(1):1362. doi: 10.1038/s42003-022-04314-8.PMID: 36509990 Free PMC article
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Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer. Advanced Biology. September 2022; DOI: 10.1002/adbi.202200197; PMID: 36084257
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A Single-Cell Landscape of High-Grade Serous Ovarian Cancer Nat Med. 2020 Jun 22. doi: 10.1038/s41591-020-0926-0. Online ahead of print.PMID: 32572264
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The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers. Trends Pharmacol Sci. 2020 Mar;41(3):183-198. doi: 10.1016/j.tips.2020.01.001. Epub 2020 Jan 31. Review. PubMed PMID: 32014341.
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Ovarian Cancer Dissemination-A Cell Biologist’s Perspective. Cancers (Basel). 2019 Dec 6;11(12). doi: 10.3390/cancers11121957. Review. PubMed PMID: 31817625; PubMed Central PMCID: PMC6966436.
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Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003. PubMed PMID: 30943406; PubMed Central PMCID: PMC6528836.
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Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism. Mol Cell Biol. 2017 Dec 15;37(24). doi: 10.1128/MCB.00328-17. Print 2017 Dec 15. PubMed PMID: 28993478; PubMed Central PMCID: PMC5705820.
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Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028. PubMed PMID: 28273451.
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Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989. PubMed PMID: 28071763; PubMed Central PMCID: PMC5234072.
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SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance. Oncogenesis. 2016 Oct 24;5(10):e264. doi: 10.1038/oncsis.2016.64. PubMed PMID: 27775699; PubMed Central PMCID: PMC5117850.
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Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight. 2016 Jul 7;1(10). doi: 10.1172/jci.insight.86829. PubMed PMID: 27482544; PubMed Central PMCID: PMC4963159.
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Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer. 2015 Nov;15(11):668-79. doi: 10.1038/nrc4019. Review. PubMed PMID: 26493647; PubMed Central PMCID: PMC4892184.
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Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24. PubMed PMID: 24762435; PubMed Central PMCID: PMC4038562.
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Emerging role for nuclear rotation and orientation in cell migration. Cell Adh Migr. 2014;8(1):42-8. doi: 10.4161/cam.27761. Epub 2013 Jan 1. PubMed PMID: 24589621 ; PubMed Central PMCID: PMC3974792.
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Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes. PLoS One. 2013;8(11):e80314. doi: 10.1371/journal.pone.0080314. eCollection 2013. PubMed PMID: 24303006; PubMed Central PMCID: PMC3841174.
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Chaperone-mediated autophagy degrades mutant p53. Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. PubMed PMID: 23913924; PubMed Central PMCID: PMC3744729.
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The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. J Mol Biol. 2013 Jun 12;425(11):2039-2055. doi: 10.1016/j.jmb.2013.02.034. Epub 2013 Mar 21. PubMed PMID: 23524135.
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In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis. J Vis Exp. 2012 Feb 17;(60). doi: 10.3791/3888. PubMed PMID: 22371143; PubMed Central PMCID: PMC3466628.
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Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024. PubMed PMID: 22340595; PubMed Central PMCID: PMC3297962.
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Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010. PubMed PMID: 22303516; PubMed Central PMCID: PMC3269166.
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Mutant p53 drives invasion by promoting integrin recycling. Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026. PubMed PMID: 20064378.
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Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol. 2009;10(11):244. doi: 10.1186/gb-2009-10-11-244. Epub 2009 Nov 30. Review. PubMed PMID: 19951400; PubMed Central PMCID: PMC3091312.
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Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol. 2008 Nov;28(22):6954-66. doi: 10.1128/MCB.00925-08. Epub 2008 Sep 15. PubMed PMID: 18794356; PubMed Central PMCID: PMC2573295.
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FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. J Cell Sci. 2008 Mar 15;121(Pt 6):895-905. doi: 10.1242/jcs.020941. Epub 2008 Feb 26. PubMed PMID: 18303050.
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RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Mol Cell Biol. 2007 Dec;27(23):8296-305. doi: 10.1128/MCB.00598-07. Epub 2007 Oct 1. PubMed PMID: 17908799; PubMed Central PMCID: PMC2169169.
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Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem. 2007 May 18;282(20):14845-52. doi: 10.1074/jbc.M606695200. Epub 2007 Mar 28. PubMed PMID: 17395594.
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Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci. 2005 Jun 15;118(Pt 12):2613-23. doi: 10.1242/jcs.02380. Epub 2005 May 24. PubMed PMID: 15914540; NIHMSID:NIHMS112405.
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Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes. Nat Med. 2001 Nov;7(11):1225-31. doi: 10.1038/nm1101-1225. PubMed PMID: 11689887.