Zhou X, Berenger E, Shi Y, Shirokova V, Kochetkova E, Becirovic T, Zhang B, Kaminskyy VO, Esmaeilian Y, Hosaka K, Lindskog C, Hydbring P, Ekman S, Cao Y, Genander M, Iwanicki M, Norberg E, Vakifahmetoglu-Norberg H.

Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors.
2025 EMBO Mol Med. 2025 Mar 7. doi: 10.1038/s44321-025-00210-w. PMID: 40055574

Puleo N, Ram H, Dziubinski ML, Carvette D, Teitel J, Sekhar SC, Bedi K, Robida A, Nakashima MM, Farsinejad S, Iwanicki M, Senkowski W, Ray A, Bollerman TJ, Dunbar J, Richardson P, Taddei A, Hudson C, DiFeo A.

Identification of a TNIK-CDK9 axis as a targetable strategy for platinum-resistant ovarian cancer.
2025 Mol Cancer Ther. 2025 Jan 28. doi: 10.1158/1535-7163.MCT-24-0785. PMID: 39873147

Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Aleksandra Gladych-Macioszek, Agnieszka Klupczynska-Gabryszak, Teagan Polotaye, Michael Greenberg, Douglas Kung, Emily Hyde, Sarah Alshehri, Tonja Pavlovic, William Sullivan, Szymon Plewa, Helin Vakifahmetoglu-Norberg, Frederick J Monsma Jr, Patricia A J Muller, Jan Matysiak, Mikołaj Piotr Zaborowski, Analisa DiFeo, Erik Norberg, Laura A Martin, Marcin Iwanicki.

Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection.
2024 2024 Jun 9; PMID: 38931171 PMCID: PMC11206249 DOI: 10.3390/nu16121816

Hunter D Reavis, Stefan M Gysler, Grace B McKenney, Matthew Knarr, Hannah J Lusk, Priyanka Rawat, Hannah S Rendulich, Marilyn A Mitchell, Dara S Berger, Jamie S Moon, Suyeon Ryu, Monica Mainigi, Marcin P Iwanicki, Dave Sb Hoon, Laura M Sanchez, Ronny Drapkin.

Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells.
2024 2024 Jan 25:e170961. doi: 10.1172/jci.insight.170961. Online ahead of print.

Doberstein K, Spivak R, Reavis HD, Hooda J, Feng Y, Kroeger PT Jr, Stuckelberger S, Mills GB, Devins KM, Schwartz LE, Iwanicki MP, Fogel M, Altevogt P, Drapkin R.

L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary.
2022 2022 Dec 12;5(1):1362. doi: 10.1038/s42003-022-04314-8.PMID: 36509990 Free PMC article

Sarah Alshehri, Tonja Pavlovič, Sadaf Farsinejad, Panteha Behboodi, Li Quan, Daniel Centeno, Douglas Kung, Marta Rezler, Woo Lee, Piotr Jasiński, Elżbieta Dziabaszewska, Ewa Nowak-Markwitz, Dilhan Kalyon, Mikołaj P. Zaborowski, Marcin Iwanicki

Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer. Advanced Biology.
2022 September 2022; DOI: 10.1002/adbi.202200197; PMID: 36084257

Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, Rodman C, Leeson R, Su MJ, Shah P,Iwanicki M, Walker SR, Kanodia A, Melms JC, Mei S, Lin JR, Porter CBM, Slyper M, Waldman J, Jerby-Arnon L, Ashenberg O, Brinker TJ, Mills C, Rogava M, Vigneau S, Sorger PK, Garraway LA, Konstantinopoulos PA, Liu JF, Matulonis U, Johnson BE, Rozenblatt-Rosen O, Rotem A, Regev A.

A Single-Cell Landscape of High-Grade Serous Ovarian Cancer
2020 Nat Med. 2020 Jun 22. doi: 10.1038/s41591-020-0926-0. Online ahead of print.PMID: 32572264

Kozlova N, Grossman JE, Iwanicki MP, Muranen T.

The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers.
2020 Trends Pharmacol Sci. 2020 Mar;41(3):183-198. doi: 10.1016/j.tips.2020.01.001. Epub 2020 Jan 31. Review. PubMed PMID: 32014341.

Farsinejad S, Cattabiani T, Muranen T, Iwanicki M.

Ovarian Cancer Dissemination-A Cell Biologist’s Perspective.
2019 Cancers (Basel). 2019 Dec 6;11(12). doi: 10.3390/cancers11121957. Review. PubMed PMID: 31817625; PubMed Central PMCID: PMC6966436.

Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO.

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.
2019 Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003. PubMed PMID: 30943406; PubMed Central PMCID: PMC6528836.

Eriksson M, Ambroise G, Ouchida AT, Lima Queiroz A, Smith D, Gimenez-Cassina A, Iwanicki MP, Muller PA, Norberg E, Vakifahmetoglu-Norberg H.

Effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism.
2017 Mol Cell Biol. 2017 Dec 15;37(24). doi: 10.1128/MCB.00328-17. Print 2017 Dec 15. PubMed PMID: 28993478; PubMed Central PMCID: PMC5705820.

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R.

Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.
2017 Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028. PubMed PMID: 28273451.

Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY.

Starved epithelial cells uptake extracellular matrix for survival.
2017 Nat Commun. 2017 Jan 10;8:13989. doi: 10.1038/ncomms13989. PubMed PMID: 28071763; PubMed Central PMCID: PMC5234072.

Sheets JN, Iwanicki M, Liu JF, Howitt BE, Hirsch MS, Gubbels JA, Drapkin R, Egland KA.

SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance.
2016 Oncogenesis. 2016 Oct 24;5(10):e264. doi: 10.1038/oncsis.2016.64. PubMed PMID: 27775699; PubMed Central PMCID: PMC5117850.

Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS.

Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition.
2016 JCI Insight. 2016 Jul 7;1(10). doi: 10.1172/jci.insight.86829. PubMed PMID: 27482544; PubMed Central PMCID: PMC4963159.

Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR.

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
2015 Nat Rev Cancer. 2015 Nov;15(11):668-79. doi: 10.1038/nrc4019. Review. PubMed PMID: 26493647; PubMed Central PMCID: PMC4892184.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS.

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.
2014 J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24. PubMed PMID: 24762435; PubMed Central PMCID: PMC4038562.

Maninová M, Iwanicki MP, Vomastek T.

Emerging role for nuclear rotation and orientation in cell migration.
2014 Cell Adh Migr. 2014;8(1):42-8. doi: 10.4161/cam.27761. Epub 2013 Jan 1. PubMed PMID: 24589621; PubMed Central PMCID: PMC3974792.

Merritt MA, Bentink S, Schwede M, Iwanicki MP, Quackenbush J, Woo T, Agoston ES, Reinhardt F, Crum CP, Berkowitz RS, Mok SC, Witt AE, Jones MA, Wang B, Ince TA.

Gene expression signature of normal cell-of-origin predicts ovarian tumor outcomes.
2013 PLoS One. 2013;8(11):e80314. doi: 10.1371/journal.pone.0080314. eCollection 2013. PubMed PMID: 24303006; PubMed Central PMCID: PMC3841174.

Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J.

Chaperone-mediated autophagy degrades mutant p53.
2013 Genes Dev. 2013 Aug 1;27(15):1718-30. doi: 10.1101/gad.220897.113. PubMed PMID: 23913924; PubMed Central PMCID: PMC3744729.

Maninová M, Klímová Z, Parsons JT, Weber MJ, Iwanicki MP, Vomastek T.

The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts.
2013 J Mol Biol. 2013 Jun 12;425(11):2039-2055. doi: 10.1016/j.jmb.2013.02.034. Epub 2013 Mar 21. PubMed PMID: 23524135.

Davidowitz RA, Iwanicki MP, Brugge JS.

In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis.
2012 J Vis Exp. 2012 Feb 17;(60). doi: 10.3791/3888. PubMed PMID: 22371143; PubMed Central PMCID: PMC3466628.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
2012 Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024. PubMed PMID: 22340595; PubMed Central PMCID: PMC3297962.

Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Brugge JS.

Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.
2011 Cancer Discov. 2011 Jul;1(2):144-57. doi: 10.1158/2159-8274.CD-11-0010. PubMed PMID: 22303516; PubMed Central PMCID: PMC3269166.

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH.

Mutant p53 drives invasion by promoting integrin recycling.
2009 Cell. 2009 Dec 24;139(7):1327-41. doi: 10.1016/j.cell.2009.11.026. PubMed PMID: 20064378.

Iwanicki MP, Brugge JS.

Transcriptional regulation of metastatic [Id]entity by KLF17.
2009 Genome Biol. 2009;10(11):244. doi: 10.1186/gb-2009-10-11-244. Epub 2009 Nov 30. Review. PubMed PMID: 19951400; PubMed Central PMCID: PMC3091312.

Vomastek T, Iwanicki MP, Burack WR, Tiwari D, Kumar D, Parsons JT, Weber MJ, Nandicoori VK.

Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction.
2008 Mol Cell Biol. 2008 Nov;28(22):6954-66. doi: 10.1128/MCB.00925-08. Epub 2008 Sep 15. PubMed PMID: 18794356; PubMed Central PMCID: PMC2573295.

Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.

FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
2008 J Cell Sci. 2008 Mar 15;121(Pt 6):895-905. doi: 10.1242/jcs.020941. Epub 2008 Feb 26. PubMed PMID: 18303050.

Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ.

RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility.
2007 Mol Cell Biol. 2007 Dec;27(23):8296-305. doi: 10.1128/MCB.00598-07. Epub 2007 Oct 1. PubMed PMID: 17908799; PubMed Central PMCID: PMC2169169.

Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT.

Cellular characterization of a novel focal adhesion kinase inhibitor.
2007 J Biol Chem. 2007 May 18;282(20):14845-52. doi: 10.1074/jbc.M606695200. Epub 2007 Mar 28. PubMed PMID: 17395594.

Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki M, Hershey ED, Beggs HE, Reichardt LF, Parsons JT.

Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells.
2005 J Cell Sci. 2005 Jun 15;118(Pt 12):2613-23. doi: 10.1242/jcs.02380. Epub 2005 May 24. PubMed PMID: 15914540; NIHMSID:NIHMS112405.

Chen X, Scala G, Quinto I, Liu W, Chun TW, Justement JS, Cohen OJ, vanCott TC, Iwanicki M, Lewis MG, Greenhouse J, Barry T, Venzon D, Fauci AS.

Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes.
2001 Nat Med. 2001 Nov;7(11):1225-31. doi: 10.1038/nm1101-1225. PubMed PMID: 11689887.