Daniel Centeno, Sadaf Farsinejad, Elena Kochetkova, Tatiana Volpari, Agnieszka Klupczynska – Gabryszak, Douglas Kung, Teagan Polotaye, Emily Hyde, Tonja Pavlovic, Sarah Alshehri, William Sullivan, Szymon Plewa, Frederick J Monsma Jr., Jan Matysiak, Mikolaj Zaborowski, Analisa DiFeo, Laura Andres-Martin, Erik Norberg, Marcin Iwanicki. The Dietary Supplement Taurine Suppresses Ovarian Cancer Growth. bioRxiv 2023.02.24.529893.

Doberstein K, Spivak R, Reavis HD, Hooda J, Feng Y, Kroeger PT Jr, Stuckelberger S, Mills GB, Devins KM, Schwartz LE, Iwanicki MP, Fogel M, Altevogt P, Drapkin R. L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary Commun Biol. 2022 Dec 12;5(1):1362. DOI: 10.1038/s42003-022-04314-8. PMID: 36509990

Sarah Alshehri, Tonja Pavlovič, Sadaf Farsinejad, Panteha Behboodi, Li Quan, Daniel Centeno, Douglas Kung, Marta Rezler, Woo Lee, Piotr Jasiński, Elżbieta Dziabaszewska, Ewa Nowak-Markwitz, Dilhan Kalyon, Mikołaj P. Zaborowski, Marcin Iwanicki. Extracellular Matrix Modulates Outgrowth Dynamics in Ovarian Cancer. Advanced Biology, September 2022; DOI: 10.1002/adbi.202200197

Tangri A, Lighty K, Loganathan J, Mesmar F, Podicheti R, Zhang C, Iwanicki M, Drapkin R, Nakshatri H, Mitra S.Mol Cancer Res. Deubiquitinase UCHL1 Maintains Protein Homeostasis through the PSMA7-APEH-Proteasome Axis in High-grade Serous Ovarian Carcinoma. 2021 Mar 22. DOI: 10.1158/1541-7786.MCR-20-0883. Online ahead of print.PMID: 33753553 

Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, Rodman C, Leeson R, Su MJ, Shah P, Iwanicki M, Walker SR, Kanodia A, Melms JC, Mei S, Lin JR, Porter CBM, Slyper M, Waldman J, Jerby-Arnon L, Ashenberg O, Brinker TJ, Mills C, Rogava M, Vigneau S, Sorger PK, Garraway LA, Konstantinopoulos PA, Liu JF, Matulonis U, Johnson BE, Rozenblatt-Rosen O, Rotem A, Regev A. A Single-Cell Landscape of High-Grade Serous Ovarian Cancer. Nat Med. 2020 Jun 22. DOI: 10.1038/s41591-020-0926-0. Online ahead of print.PMID: 32572264

Kozlova N, Grossman JE, Iwanicki MP, Muranen T. The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers. Trends Pharmacol Sci. 2020 Jan 31. pii: S0165-6147(20)30001-8. DOI: 10.1016/j.tips.2020.01.001.

Farsinejad S, Cattabiani T, Muranen T, Iwanicki MOvarian Cancer Dissemination-A Cell Biologist’s PerspectiveCancers (Basel). 2019 Dec 6;11(12). DOI: 10.3390/cancers11121957. Review. PubMed PMID: 31817625.

Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO. Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019 Apr 2;27(1):255-268.e6. doi: 10.1016/j.celrep.2019.03.003. PMID: 30943406

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R. Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer. Cell Rep. 2017 Mar 7;18(10):2343-2358. DOI: 10.1016/j.celrep.2017.02.028. PubMed PMID: 28273451.

Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017 Jan 10;8:13989. DOI: 10.1038/ncomms13989. PubMed PMID: 28071763; PubMed Central PMCID: PMC5234072.

Sheets JN, Iwanicki M, Liu JF, Howitt BE, Hirsch MS, Gubbels JA, Drapkin R, Egland KA. SUSD2 expression in high-grade serous ovarian cancer correlates with increased patient survival and defective mesothelial clearance. Oncogenesis. 2016 Oct 24;5(10):e264. DOI: 10.1038/oncsis.2016.64. PubMed PMID: 27775699; PubMed Central PMCID: PMC5117850.

Iwanicki MP, Chen HY, Iavarone C, Zervantonakis IK, Muranen T, Novak M, Ince TA, Drapkin R, Brugge JS. Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight. 2016 Jul 7;1(10). pii: e86829. PubMed PMID: 27482544; PubMed Central PMCID: PMC4963159.

Bowtell DD, Böhm S, Ahmed AA, Aspuria PJ, Bast RC Jr, Beral V, Berek JS, Birrer MJ, Blagden S, Bookman MA, Brenton JD, Chiappinelli KB, Martins FC, Coukos G, Drapkin R, Edmondson R, Fotopoulou C, Gabra H, Galon J, Gourley C, Heong V, Huntsman DG, Iwanicki M, Karlan BY, Kaye A, Lengyel E, Levine DA, Lu KH, McNeish IA, Menon U, Narod SA, Nelson BH, Nephew KP, Pharoah P, Powell DJ Jr, Ramos P, Romero IL, Scott CL, Sood AK, Stronach EA, Balkwill FR. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat Rev Cancer. 2015 Nov;15(11):668-79. DOI: 10.1038/nrc4019. Review. PubMed PMID: 26493647; PubMed Central PMCID: PMC4892184.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest. 2014 Jun;124(6):2611-25. DOI: 10.1172/JCI69815. Epub 2014 Apr 24. PubMed PMID: 24762435; PubMed Central PMCID: PMC4038562.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14;21(2):227-39. DOI: 10.1016/j.ccr.2011.12.024. PubMed PMID: 22340595; PubMed Central PMCID: PMC3297962.

Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Brugge JS. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011 Jul;1(2):144-57. DOI: 10.1158/2159-8274.CD-11-0010. Erratum in: Cancer Discov. 2011 Dec;1(7):626. Ince, Tan [corrected to Ince, Tan A]. PubMed PMID: 22303516; PubMed Central PMCID: PMC3269166

Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Mutant p53 drives invasion by promoting integrin recycling. Cell. 2009 Dec 24;139(7):1327-41. DOI: 10.1016/j.cell.2009.11.026. PubMed PMID: 20064378.